The relation of peptide bonds, disulphide bonds and sulphydryl groups to urogastrone activity
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چکیده
منابع مشابه
Protein disulphide-isomerase and the formation of native disulphide bonds.
Disulphide bonds are found in practically every class of extracellular protein, and the formation of disulphide bonds must be regarded as a key post-translational modification of secretory proteins. Despite this, and despite the fact that the existence of disulphide bonds has been known for many years, the mechanism of disulphide bond formation during protein biosynthesis and secretion is not w...
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The observed V3 torsional barriers measured by microwave spectroscopy for nine methyl groups attached alpha to peptide bond linkages in five gas-phase biomimetics have been found to differ considerably from one molecule to the next and even depend on the position of substitution, being sensitive to structural changes at the other end of the peptide bond. In the search for an explanation for the...
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Growth hormone (GH) structure is stabilised by two disulphide bonds, C53-C165 and C182-C189 in human GH. Researchers have investigatedthe role of these structural features since the late 1960s. Early studies implied that the disulphide bonds would not be importantfor biological activity of GH. However, more advanced techniques, as well as clues from patients carrying mutations in their GH1 gene...
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Peptide bonds, polypeptides and proteins printable pdf We have already mentioned proteins, since there are few biological processes that do not rely on them. Proteins derive their name from the ancient Greek sea-god Proteus who, like your typical sea-god, could change shape. The name acknowledges the many different properties and functions of proteins. Proteins can act as catalysts and regulato...
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The H-bond inventory approach is used commonly to interpret data involving changes in the number or types of protein hydrogen bonds. I point out here that this approach gives an incorrect answer either for the standard free energy or enthalpy of the reaction between simple amides and water. On the other hand, an electrostatic solvation approach fits almost within error the polar solvation free ...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1962
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1962.sp006924